Correlation of Vitamin-D levels and essential hypertension in urban adolescent population.

Chandan Kachru, Dr. Ragini Aggarwal, Dr. Charu, Dutt Arora, Divyah Jain, Divyam Kaushal

Introduction: New research and data show that vitamin D could be a risk factor in many chronic diseases like

hypertension, dyslipidemia, diabetes mellitus, cardiovascular disease, some cancers, auto-immune disease, and tuberculosis. There is an inverse relationship between the plasma 1,25 (OH)2D3 concentration and the blood pressure and/or the plasma

renin activity in both normotensive men and patients with essential hypertension. Furthermore, it has been reported that vitamin D3 supplementation reduces blood pressure in patients with essential hypertension.

Aim & objectives: To determine the serum 25-hydroxy vitamin D levels in urban adolescent patients with primary hypertension to demonstrate any correlation between vitamin D and hypertension.

Methods: 70 patients (age group 12-19 years) who are primary hypertensives were selected and their vitamin D levels were measured and their vitamin D levels were compared to age and sex-matched non-hypertensive controls.

Results:70 hypertensives cases and 70 non-hypertensive attending to OPD and inpatients coming to a tertiary care hospital in Urban Gurgaon were evaluated for vitamin D status. The hypertensive had lower vitamin D level status of deficiency in 23(32%) of the cases and insufficiency in 30(42%) of the cases and normal showed normal levels in 17(24%) cases. Non-hypertensive controls showed normal vitamin D status 52(74%) of controls and insufficiency in 13(19%)of the controls and deficiency in 5(7%) of the controls. Age, duration of hypertension, systolic blood pressure and diastolic blood pressure inversely correlated to vitamin D levels.

Conclusion: it was observed from this study that serum vitamin levels were lower in hypertensive adolescent patients when compared to non- hypertensive controls. Vitamin D could be an independent risk factor that is associated with primary or essential hypertension. It becomes imperative for public health strategy in implementing Vitamin D levels monitoring early in the age of adolescence so that we can avoid the exposure to various chronic non-communicable diseases. Further studies with an urge number of participants are required to confirm the ecology of vitamin D deficiency in Primary Hypertension.

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